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The Currency of Ageing – Florey Institute
11/11/2021 @ 11:00 am - 12:00 pmFree
This Florey Institute lecture will explore a fundamental process of biological ageing and examine approaches that may be used to improve late life frailty. Book through Eventbrite
About this event
Life has evolved to use the chemistry of iron. Iron is essential for both health and development, with a particularly high demand in early life. However, humans like all animals, lack a regulated means to get rid of excess iron. Consequently, we accumulate iron in various tissues and organs as we age. Our biochemical dependence on iron has established an inevitable liability in late life.
To combat unregulated cell growth (i.e. cancer) in later life, a regulated and iron-initiated cell death program called ferroptosis has evolved. We believe that frailty in late life is determined by the inevitable accumulation of iron, and inappropriate triggering of cell death by ferroptosis, which leads to impaired function and ultimately limits lifespan.
MEET THE SPEAKER
Associate Professor Gawain McColl graduated with a PhD in Genetics (Monash) in 1999 before heading abroad to gain further research experience in the UK and United States. In 2013 he established an independent group at the Florey Institute of Neuroscience and Mental Health to explore the fundamental biology of ageing and how ageing impacts on diseases of the brain.
The research group of Associate Professor McColl uses a combination of genetics and analytical approaches that explore how biological systems lose their ability to regulate essential elements like iron during ageing and the consequences for specific tissues like the nervous system with the aim to identify new strategies to improve late life outcomes.